The aim of this course is to provide the students the basics of enzymology, such as classification, types of inhibition, regulation, coenzymes and an introduction to bioenergetics. I will be handling the topic bioenergetics.
We will be discussing the following topics in this module
Redox reactions, redox potential
and free energy, mitochondrial electron transport chain, coenzymes and
prosthetic groups of respiratory chain enzymes- sites of ATP production, P/O
ratio, inhibitors of electron transport chain, oxidative phosphorylation-chemiosmotic
hypothesis (outlines only), uncouplers of oxidative phosphorylation. Formation
of ATP-oxidative and substrate level phosphorylation. High energy compounds
with structures (ATP, ADP, Creatine phosphate, 1,3 bisphosphoglycerate, PEP
etc). Role of high energy phosphate groups